Ocular Drug Delivery System - ADI YUGATAMA

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Sistem Penghantaran Obat Melalui MataPresented by Adi Yugatama S Farm Apt Jurusan Farmasi FKIK Kesulitan yang muncul pada studipenghantaran obat melalui mata manusia.
SULIT UNTUKMENGGUNAKANMEMPEROLEHMODEL HEWAN MENURUNKAN.
JARINGAN MATAISOLASI ORGAN AKURASI DANMENGANDUNGKOMPATIBILITAS Mata manusia terdiri dari 1 Sclera lapisan luar mata.
berwarna putihdan relatif2 Choroids lapisan kayaakan pembuluh darah dansel sel pigmen.
pigmen sehinggaberwarna hitam Inner Endothelium lipophilic 3 Cornea memfokuskanCornea memfokuskan Middle Stroma hydrophilic .
mata Outer Epithelium lipophilic 4 CilliaryCilliary Body Body Sekresicairan mata.
5 Lens bagianLens bagian yang6 Retina Retina mengirimkanmengirimkan.
pesan visualpesan visual melaluimelalui syarafoptikus ke7 Conjuctiva .
Conjuctiva selaputselaput tipisyang melapisimelapisi bagiandalam kelopak.
kelopak matabagian luar sclera8 VitreousVitreous Compartment Compartment .
gel transparangel transparan didi belakanglensa dan di depan retinaPupil daerah.
daerah hitamtengah tengahtengah tengah iris MELINDUNGI BARRIERMATA BAGIAN BLOOD .
MELINDUNGIMATA BAGIANLAPISAN PELINDUNG MATA POINT PENTING UNTUK OPTIMASIPENGHANTARAN OBAT MELALUI MATA.
Improving ocularcontact timeEnhancing cornealpermeabilityEnhancing site.
specificity Outer Epithelium rate limiting barrier dengan ukuran pori Corneal60 hanya bisa untuk ion kecil molekul lipofilik Absorption Trans cellular transport transport between cornealepithelium stroma .
Penetrasi melalui Sclera Conjuctiva untuk masuk ke Non Cornealdalam jaringan mata Absorption Non Productive karena penetrasi obat diabsorpsi kesirkulasi umum Mekanisme Absorpsi Melalui Mata.
General Pathway For Ocular Absorption Faktor yang Mempengaruhi BioavailabilitasIntraocular 1 Pemasukan dan pengeluaran dari Lacrimal fluids 2 Efisiensi pengeringan naso lacrimal .
3 Interaksi obat dengan protein dari Lacrimal fluid 4 Pengenceran dengan air mata Peran Polymer di ODDS Viskositas Larutan Pengeringan Larutan Pembawa Polymer Mucoadhesive Tertahan di mata.
melalui ikatan non kovalen dengan conjuctival mucine Mucine dapat mengambil 40 80 kali dari berat air PERAN MUCOADHESIVE PADAMUCOADHESIVE BETTEREXTENDS PRE.
RETAINED IN OCULAREYE BY NON ABSORTION Classification Of Ophthalmic Dosage Form A Based on Route B Based onof Administration Physical Form.
1 Topical Soln Multiple Dose 1 Aqueous Soln container With Preservatives 2 Intra ocular Soln For 2 Suspension Surgery Single dose Without 3 Ointments preservative .
3 Ophthalmic Soln Injections 4 Gels Intra ocular injection given ineye tissues without 5 Eye Lotions preservative 6 Solid Inserts .
Ocular Control Release System Ophthalmic InsertsDefinition Dipreparasi secara steril dengan bentuk padatatau setengah padat ukuran dan bentuk tertentu untukpemberian pada mata dan terdapat polimer yangmengandung obat .
Kriteria yang Diinginkan Untuk Control ReleaseOcular Inserts reprodusibelnya pembuatanNyaman dalam.
pelepasann penggunaan Sterilitas StabilitasMudah Kemudahan Advantages Limitations1 Dosis akurat 1 Pasien merasa seperti ada2 Tidak ada pengawet benda asing .
3 Meningkatkan shelf life 2 Pergerakan di sekitar mata karena tidak adanya air 3 Kadang hilang pada saat tiduratau mengucek mata 4 Menganggu penglihatan 5 Sukar saat menempatkan atau.
mengambil Types Of Ocular Control Release System2 Contact Lenses B Erodible1 Lacrisert 1 Ocusert.
A Non Erodible 2 SODI3 MinidiscD LiposomeC Nanoparticle A Non Erodible .
1 Ocusert Developed by Alza Corporation Oval flexible ocular insert Release Rate 20 40micro gm hr Consist of .
Part Material Drug Reservoir Pilocarpine Carrier material Alginic acid Rate controller Ethylene vinyl acetate copolymer Energy Source Conc Of Pilocarpine.
Delivery Portal Copolymer membrane Annular ring Impregnated with Ti02 For Visibility Kelebihan Kekurangaocusert n ocusertControlled rate Patient.
of delivery uncomfortPlacement andGreater drug removal of insertabsorption 2 Contact Lens .
Contact lens digolongkan menjadi 3 tipe yaitu soft semi soft dan hard contact lens MARKETED PRODUCTS LENS B Erodible Inserts1 Lacrisert .
Alat berbentuk tangkai steril Komposisi HPC tanpa preservatif Berat 5mg Dimension Diameter 12 5 mm panjang 3 5mm Penggunaan Dry eye treatment Keratitis Sicca .
MARKETED PRODUCTS LACRISERTS Click icon to add picture 2 SODI Soluble Ocular Drug Insert Alat yang larut air berbentuk oval kecil .
Komposisi Acryl amide Vinyl Pyrolidone Ethylacrylate Berat 15 16 mg In 10 15 sec Softens In 10 15 min turns in Viscous Liquids After 30 60min Becomes Polymeric Solution .
Keuntungan 1 Menggantikan 4 12 kali pemberian obat tetes mata 2 Menggantikan 3 6 kali pemakaian ointment Untuk pengobatan sehari pada Glaucoma dan 3 Minidisc .
Minidisc terdiri dari counter disc yang bagian depan berbentukConvex bagian belakang berbentuk Concave yang kontakdengan bola mata Diameter 4 5 mm Komposisi Silicon based pre polymer .
Hydrophilic or Hydrophobic Pelepasan obat dapat selama 170 jam Pada gentamycin sulphate dapat meningkat hingga 320 jam C Nanoparticle Ukuran 10 1000 nm.
Obat didispersikan dienkapsulasi atau diabsorpsi Sistem partikel pada penghantaran obat nanopartikel Polimer yang digunakan Biodegradable Ex polyalkylacrylatesTipe Nanospheres dan Nanocapsules.
Nanospheres adalah lapisan monolitik solid kecil yangterbuat dari jaringan polimer solid yang rapat Nanocapsules adalah tempat penyimpanan kecil yangterdiri dari rongga sentral yang dikelilingi membran D Liposome.
Sifatnya biodegradabel dan tidak beracun Vesikula terdiri dari membran lipid yang dikelilingi oleh cairan Terbentuk ketika matriks phospsolipids berada pada media cairan danterdispersi ke dalam 2 fase Phospholipids used are Phophotidylcholine Phophotidic acid .
Sphingomyline Phosphotidyleserine Cardiolipine ADVANTAGES Obat yang dihantarkan tetap utuhpada berbagai jaringan tubuh .
DISADVANTAGES OF Liposomes dapat digunakan untuk LIPOSOMESobat hydrophilic dan hydrophobic Memerlukan modifikasi banyak Lebih tertarget dan menurunkanuntuk penghantaran obat ke.
toksisitas obat Ukuran muatan dan karakteristik organ organ khususlain dapat diubah tergantung dari Harga obat dan jaringan yang dituju .
Preparasi Liposome Reference N K Jain Advances in Controlled Novel Drug Delivery CBS Publication distributor New Delhi pg No 219 223 Remington Gennaro The Science Practice Of.
Pharmacy Mack Publication Company Easton Pennsylvania Pg No 1563 1567 Web Sites www vision care guide com www google images eye anatomy physiology.
www pharmainfo net reviews rec... drug delivery system Thank You The eyes are the mirror of theTake care of your eyes with.
gentleness POINT PENTING UNTUK OPTIMASI PENGHANTARAN OBAT MELALUI MATA. Improving ocular contact time. Enhancing corneal permeability. Enhancing site specificity. Mekanisme Absorpsi Melalui Mata. Non-Corneal Absorption. Corneal Absorption. Penetrasi melalui Sclera & Conjuctivauntuk masuk ke dalam jaringan mata.

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